Make sure you don't have the NI discovery service running, or any VISA drivers. Apart from being flaky like all h*ll they can "steal" devices from your python-vxi11 client if they discover the ICS 8065. I've had an Intel NUC D54250WYK with Linux sit and collect data from an assortment of instruments for days using an ICS 8065 with nary a glitch. The only glitch is a K2001 DMM sometimes locks up, but I design my tests so they checkpoint state and can resume if interrupted, and it has only happened twice so far - so no big deal. The K2001 might need a firmware update. (Mine's B13; I see xdevs.com wants an upload of it, maybe I can oblige.) The only problem device I have is a vintage HP8903B with HP-IB that predates SCPI, and its only means of readout is via async SRQ, which python-vxi11 doesn't support. Fortunately I don't use that one much, but I'm definitely sticking to GPIB and SCPI for all future instruments. Otherwise, between the ICS 8065, python-vxi11, numpy, scipy, matplotlib, it's super easy to whip up two-part tests (one to collect data, the other to analyze and plot the results). I do keep the NUC+8065 on a VLAN dedicated to instruments.