Hmm, you must've used an older one. The ones that are currently available on the website are all +/-20V, with 100V maximum input. Not great compared to a bench scope, but good enough for 99% of the stuff. You can get cheap 20:1 attenuators for higher voltage use.
I don't see the problem with the user interface. Dragging a trace with the mouse is just as fast if not faster than turning a rotary knob. And doing stuff like changing trigger options is way more tedious on a normal scope. Unless you're using one of the high end Windows based scopes where you can attach a mouse and where the user interface is just a Windows program.
One big advantage is that doing screenshots, waveform captures, etc. is much faster as you already have everything on your PC. Not to mention decoded serial data. Also, you can directly access the scope data from other apps, like MATLAB, using the SDK.
What I like about the Picoscope is the no-bullshit software policy. Same software for all models, no paid options to unlock and quite a number of serial decoders. Also, there's a Linux version available. Even better, they have a Debian repository.
The reason I was asking is because I'm about to pull the trigger on a 2204A ... 130 Eurobucks (including probes) is a decent price.