At least for the versions that I've used in the past, there wasn't any specific key for VXI, just the option for hardware connectivity, which let it connect with anything supported by that version. At some point, the E4406A dropped of the list of supported hardware, but someone figured out a hack to get it back. The trick with getting VXI or ANYTHING working with VSA was making it happy with Agilent IO libraries first. After that I often struggled with getting all the settings right in VSA. If you didn't change anything, the next time you launched VSA it would be setup like last time... unless there was a hiccup in which it would revert to "simulated hardware". But if you changed instruments, it always took some fumbling to get everything right in IO libraries and VSA.
Another thing I dabbled with but never really used was using file input. You can have VSA take it's input from a file. Just make an app that dumps your instruments output to the appropriate file format. You might even be able to use the demo version for that (which I think doesn't have a 30 day timeout). It just displays "Demo" on the screen (at least it used to when I used it).