Anything who goes on the net is not to be trusted, sorry whatever the OS is.
For metrology or any test equipment you use a closed network, you need to add files or programs you use an usb key or any medium you can scan for virusses or threats before plugiin / putting it in the closed network
"Trustable" machines is not a perfect term, since i worked in a military coumpound i know a few things, trustable people is important too.
You close every usb ports, disable floppys, disable dvdr drives etc ... scan for open gateways or ports, you get the idea we had only one computer who could go on the net, isolated from everything, anything downloaded was screened multiple times.
But it get contradictory if you need as wrote earlier to add files or programs, you get vulnerable at this point until the task is done, and you have to do checks aftewards.
The threats are the people, the machines and the transport mediums you use to do your job.
A good rule in network settings is to accept only identified and permitted mac adresses, good firewalls, nat translations, updated antivirus, kill non authorized wi-fi or Bluetooth signals, the list goes on. We used Fortinet based routers, they almost blocked everything lolll maybe too much.
One thing i've seen good, are deepfreezed machine(s), works wonders in many cases, a single reset cleared most of the damadges.
Even now a single image may contain bad code(s), an mp3 can do bad things too, any documents .... i'm not paranoid, but Ive seen too many things loll