I own both the Analog Discovery 2 and the Keysight EDUX1002G. I do not work with Audio applications, so I do not have the knowledge to compare both in terms of audio, but if you suggest some tests I can run, I will post the screen captures with the results. For signal generation I can use the Wavegen included in the EDUX1002G or I have a Rohde and Schrawz CMU200 (Communications Test Equipment) that can generate audio and do THD%.
Even when the AD2 has 14-bit ADC, I found it to be very noisy at 10mV and lower scales (it can go as low as 10uV/Div) and the refresh rate is nothing near the EDUX1002G.
For pure digital stuff like vintage computing, I use an old HP 1670G logic analyzer and if I need protocol analysis, I use the Zeroplus LAP-C 16032 (PC based USB logic analyzer) that has over 100 protocol decoders included for free in the software. I still do not have the serial decode option for the EDUX1002G ($150 for just i2c and UART seems to be overpriced).
It is my understanding that the serial protocol decoder on the Keysight EDUX and DSOX series are hardware based, so you get real time decoding. I tried it on the Rigol and it is slow, but has a lot of capture memory and you can do post capture analysis. The logic analyzer on the Analog Discovery 2 works in a similar way to the Zeroplus, capture and send the data to the PC for posterior analysis, but I have not played a lot with the AD2 protocol decoders as I was already using the Zeroplus on a daily basis.
The AD2 can do pattern generation on the 16 digital channels, which is a plus if you need this functionality.