Yes, lots of them. In private, my stuff is web-based or on alternative mailclients, but in a corporate environment, that is centered around a windows domain, you quite often have an exchange server and Outlook as its native and natural client.
I tried to pitch some proposal to replace the Exchange system at my workplace last year, but quickly realized that all the alternatives in the Linux world like Zimbra lacked some features or functionality- so boss did not approve of this.