Normally it's not the IC that causes coupling problems, it's the stuff attached to it, especially inductors. Every circuit generates two fields, an electrostatic field and a magnetic one.
The electrostatic field is easily dealt with by using a small amount of shielding around the circuit, often you can get away with just a vertical shield without a top. The magnetic field is the tough one and in the past engineers used something called mu metal to shield things like oscilloscope tubes from the magnetic fields inside the case (especially from the power transformer).
As a rough guide I would have a minimum space around a shielded inductor of 1cm with a 3cm space around an unshielded coil. Things can be improved by laying out your PCB so that adjacent inductors are at right angles to each other, the following picture illustrates this well:
http://wimo.com/bilder/om-6bpf-open-2-l.jpgFinally, wiring. Wires can also radiate a field and the best way of dealing with this is to route all of your wires along the sides of the shields and the chassis rather than leave them floating in mid air. You then have the option of covering them with a layer of copper tape for 100% shielding.
Two ICs? just put them next to each other.