With a mains LISN, the priority is RF signal integrity, not safety. ...
I am not a lawyer but I believe the health & safety legislation in every civilized country would take exception to that statement. If there was an accident involving equipment made/supplied by you, that statement would bite you very hard. The priority should always be safety first.
How could you possibly ever get agency approval for a high voltage generator, a transient generator, an EMI generator, a... ?
Test equipment is exempt from such restrictions for good reason. They must be used by qualified technicians, in suitable lab conditions, for the same reason!
Example: the local Cooper/Eaton guys have a high voltage test lab, 20kV just sitting out in the air and all that.
How is that acceptable?
It is carefully caged behind a full height chain link fence, with several redundant interlocks. On top of that, they are very particular about their procedures: measuring voltage twice with a meter, to ensure a de-energized state; shorting anything that needs to be guaranteed safe while handling; wearing heavy rubber gloves; only allowing qualified personnel into the area (i.e., I watched from behind the fence), and so on.
For the LISN, there isn't much you can do that fits within ordinary safety rules. You do want to address ground leakage and galvanic isolation, using an isolation transformer. This also allows you to plug it into a RCD/GFCI circuit. Fusing isn't needed on the network because the isolation transformer or mains circuit has it. The filtering somewhat addresses mains transients as well (which is where the 2.5kV hazard comes from), and if you provide any additional protection, that helps too.
Tim