Just to follow up... I ended up getting this open, though it wasn't exactly a success. So, I'll post my thoughts/advice/pics for anyone else (or the future me, if I come across another really cheap sensor).
To get into the sensor, you can see a flat spot on the side where you'd expect the two halves to join together. In this case, it's sealed, so you need to carefully cut around the edges and sorta pry it apart (I used a sharp new X-acto knife blade). It's small, so you'll want some magnification (I did it under a microscope).
The mistake I made was cutting closer to the top of the flat spot (side that the cable goes into) instead of bottom (side that says "GENDEX"). After opening it, I can see that the bottom goes inside the top (i.e. there's a lip, which you can cut to, without the knife blade going into the electronics). Also, specifically be VERY careful on the end where the cable points out of... the bond wires to the image sensor are RIGHT behind the plastic and completely unprotected. Some of mine look to have gotten mangled (not sure if I put the knife through them, pushed plastic into them, etc).
I originally suspected a bad USB cable, but once I got into it, I was able to check the cable, and it was fine (cable is soldered to a flex circuit on the top, which comes down to the connector on the board). There are no electronics in the USB plug... it's straight USB wires into the sensor. When the sensor is plugged into the PC, it doesn't enumerate, so something on my board must be broken (in addition to the now broken bond wires).
It looks like they used a two-part gap filler, which generally don't reuse well... I dunno how hot these sensors get, but if you open it, you might want to replace it with a new gap pad or something.
Also, if you really suspect just a bad USB cable, the easiest/safest way to fix it is probably to cut the plastic lump off the top where the cable goes in, and re-terminate the cable there. That way you don't risk damaging any other parts by opening the sensor portion.
Couple pics attached...
Pat