Sensor Resistance Rsens = 19.96*0.113*temp. Input voltage Vin = 5V * Rsens/(Rsens + R1). Output voltage Vout = (Vin-Voffset)*Gain. Voffset = 0.0723V, divided by R2, R3 to get approximately the same voltage as Vin at 22oC, Gain = 17.6. For R4 calculation to get required opamp gain, it can be approximated that R6 is connected to GND since R2, R3 divider has negligible output resistance.