It's a DAC, it's got all the sense and feedback right there, or as low a source impedance as you like; even a basic DAC like MCP4922 has a Ro of some ohms, that's 32 bits against a 10^10 ohm shunt, vastly in excess of its 12b capability. I assume any DAC for higher bits also uses buffering (whether internal or external); wiring an R2R or whatever straight to an output would be silly. And, with other connections, leakage can be bootstrapped anyway. (Which also goes for ESD protection devices.)
Unless this is a far more limited instance than I imagine, but I've seen nothing to suggest this would be a problem.
Maybe there's something about the "isolate" vs "ground" functions that I'm not imagining the topology of. Isolation seems redundant as an unpowered DAC isn't going to produce much output anyway, so the shunt dominates; that seems pretty trivial to me.
Tim