One of the reasons I'm seeing more commercial projects these days with the RP2040 is precisely due to its availability, so you're not alone.
Apart from what uer166 said, minus points are also that it has unimpressive power consumption for a Cortex-M0+ compared to the competition. In particular, it has no decent "deep sleep" mode, so power consumption is going to be a problem for many battery-operated applications. I think the lowest that has been measured in deep sleep was about 300 µA - and even that was achieved with great care. The competition routinely achieves 100x less. If power consumption is not an issue for your application though, it's fine.
Another point is that it's the first MCU from the RPi - trust can be an issue. In the same vein, nobody really knows the intentions of RPi for the future. How long is this product going to last, and will there be successors? Nobody knows. One related point is more general with the RPi: this is a foundation and its goal is not to consistently supply businesses with parts. It is, at best, ambiguous about that point.
Now if the listed minus points are not a problem for your application and your own business, go for it. It's a great chip for what it is and again, it happens (at least for now) to be easily available, which is rare enough at the moment to be noted.