I looked at the datasheet before answering. The mux consists of a conventional CMOS transfer gate. While no details are given about input protection the datasheet specifies HBM/MM/CDM performance which would indicate serious diode junctions of both flavors on all inputs. Thus I suspect it unlikely that a truly floating node would bump up against a supply and cause crosstalk via power rails. Crosstalk voltage levels between the rail potentials is whatever it will be regardless of whether the signal is floating or forced.
It is not crosstalk via the power pins.
The problem comes about with junction isolated IC processes where the substrate is connected to the negative supply. Negative going signals are clamped by the diode to the negative supply but still inject carriers into the substrate. That is how junction isolated CMOS processes can die from SCR latchup even though they have input protection diodes.
It is more of a problem with multiplexers because the substrate current can leak into other channels. For this reason, some multiplexers are deliberately built on dielectric isolated processes making them immune to this problem. JFET multiplexers may be immune also although I am not sure. Another way I have occasionally seen used with very old junction isolated multiplexers is to bring the substrate connection out separately and require it to be tied to a more negative voltage.
Is it a real problem? At high resolutions it sure is. For 3.5 digits, leakage is unlikely to be an issue.