For EMC, slots in
ground planes are more common (although, used carelessly, they're as often
sources!), but if you need that extra teensy fraction pF of isolation, it can be mechanically slotted as well. Of course for high voltage, it helps even more (creepage, clearance).
That said, most often, around an isolation barrier, the absolute minimum capacitance is
not desirable. Rather, a modest amount (perhaps ~pF up to several nF), in combination with damping, helps to somewhat reduce very high frequencies and dV/dt at the isolation barrier.
The damping might be an R+C across the isolation barrier, or a ferrite bead somewhere, perhaps on the isolation capacitor, or on the cable or connecting traces going from the isolated sections to their respective main circuits.
The goal isn't really to filter high frequencies, because that's practically impossible (it would probably take ten kilos of ferrite, and huge cable lengths bound up in it, to filter e.g. a high side gate driver's full isolation voltage), but just to take the edge off, and control ringing.
If low isolation capacitance is a priority, it'd be worth buying some medical grade power supply modules (e.g. from Meanwell, etc.) and inspecting their design. They achieve impressive results with little capacitance, probably through a combination of tricky circuit design and construction (e.g., balanced and/or shielded transformers), and optimizing the filtering (so it does as well as it can, with a minimum of capacitance).
Oh, and the slots used in said power supplies are for safety/isolation, of course.
The thing to realize about RF is, it's all about controlling impedances. There isn't really an open circuit. Short circuits are reasonable. So, you can't really have an "open circuit", you can only filter (into a controlled impedance, because filters only work that way), or shunt or shield it away. That's why the best RF kit is made out of machined metal bricks...
Tim