The picoampmeter should have close to zero ohms input impedance, thus the signal line will be near zero volts. If you simply shield it with a zero potential shield, that should take care of things. What you need is guarding, nothing more than a trace on each side of the signal line, connected to ground, to insure that no voltage sources can communicate with the signal line. The problem is that you'll only have half or less the number of contacts on your connector because every other contact needs to be a ground connection. Basically, if you can draw a line on any surface, from the signal line, to any voltage source, you need a zero volt guard separating the two. Guarding can also be used with non-zero signals by buffering the source and then driving the guard trace or shield such that there's always zero voltage difference to the signal. Ohms law says that with zero voltage, the current through a resistor should be zero.