Your software will need to derive the resistance of each of the 6 RTDs. I suggest to assign actual numbers (e.g. PT100 vs PT1000, resistor values, IDAC currents, etc) and:
1. Write the formulas for the 6 resistances.
2. Verify that you are within the working range of the ADS124S0x (e.g. the input voltages that you get on the ADC and reference inputs).
3. Compute the expected worst case resolution (ideal ADC steps / Ohm, at the worst temperature points).
The second design is more intuitive because the resistance formulas are independent for each channel (#1 above).