I cannot say I have any experience driving x-ray tubes, or much in the way of glassware, but I suggested a "spark gap" as a safety measure... whether or not you need one depends on how you are driving it. I would have thought some large value resistors in series are in order.
Often "flybacks" are just that - used in a flyback converter, which is where the transformer stores energy in the core, and current does not flow in the primary and secondary at the same time. A result of this is that when then primary is turned off, the field collapses, current is induced in both windings, and they will achieve whatever voltage is necessary for current to flow - even when that voltage is so high it breaks down the insulation between windings. It is essentially an inductor with two windings. I'm saying this because without a way to limit this voltage, you can pretty much ruin a flayback......
When driven with AC, or rather in a royer type converter the output voltage is a result of the primary peak voltage and the turns ratio - just like a standard transformer. I believe a ZVS driver is more like this type, and so, its output voltage will be limited by turns ratio and input voltage. This is very much a good thing, it means you can achieve your ~50kV by the input voltage - but this would still require some sort of feedback, unless you know the turns ratio in advance. So, I don't think a spark gap will be required if you use this driver - but it is probably wise as a secondary safety measure. at 50kV I'd say ~20mm would be about right (complete guess!).
Not trying to over-complicate matters but if you look at CCFL drivers, these use feedback to control a buck converter - which then feeds the transformer driver (usually a resonant royer converter). This is so the output can be somewhat regulated, and varied. I realise you are not driving CCFL's - which have their own conditions - but it is an example of an high voltage power supply that is controllable, something I think you may require. And at 10W an off-the shelf buck converter module could be used to drive it.
I'm assuming you're not going to hook up the tubes during testing, just to make sure you have a stable supply that provides roughly the correct voltage.
Maybe I'm over thinking this but I have seen many "down and dirty" setups made just to make bit fat sparks that end up working for a few seconds before ruining the secondary winding, or blowing parts left right and centre. If you relaly only need 50kV @ 10W I'm thinking a smaller transformer, with many stages of voltage multiplier would be better. The sort of Flyback transformers used in tv and monitors are capable of much higher powers when driven with a ZVS. 60W+