Do you have an enclosure in mind? It's always easier to make a PCB fit an enclosure than find an enclosure to fit an arbitarily designed PCB.
Ahh, well, the dreaded issue of enclosures. In the past decades i found that it is close to useless to design DIY stuff for some specific enclosure. The markets are way too different to even come close to a common denominator here. For example, in the US market you see Hammond very often. In Europe they are more of a curiosity, however. In Germany you see things like Bopla or OKW very often (BTW, check out OKW. They make _really_ nice enclosures!), but overseas they are basically unheard of.
The current PCB is exactly 91mm x 91mm. It has four mounting holes in the corners. The FET final sits in a cut-out inside the PCB. The reasons for that are various. For one, there are 100mm x 100mm heatsinks available. Or any other heatsink in a plain square format with roundabout the same dimensions. So the PCB would be mounted directly onto that heatsink, allowing the FET to be mounted on there as well. Since the heatsink is massive aluminium, it acts as a shield as well in that direction.
Then, all the connections are done as solder pads, and the header is also placed on the board in a way that does not require any "sideways" stuff. So the controlling/supply PCB can be stacked directly onto it. Using hex standoffs, they can act as the screws to mount the RF PCB on the heatsink, while allowing the control/supply PCB screwed on top of that. Like a sandwich.
What goes around is completely up to the folks building that thing. I would go for sheet aluminium and 90° aluminium profiles, all stuff that is readily available. A heatsink usually has a thick enough base to allow tapping in of threads on the sides.
Or the whole thing can be screwed into some die-cast metal box. There are many options, actually. In any case, i'm definitely not going to plan the PCB for a specific enclosure. Too much trouble down that route....
Oh, since 100x1600mm for example is a standard format, at least here in Europe, for PCB's (heck, that format is even called "Euro-Format"), there are plenty of enclosures available where it will fit into. For example that stuff that is basically extruded aluminium profiles with sheet aluminium as the front/rear panels (and sometimes top/bottom). So, with the PCB size i have chosen there should be little problems to find a suitable enclosure.
Greetings,
Chris