I was thinking about it a bit and I thought of an idea.
Isolation on chassis level would be complex and not needed by everyone (for example for my use cases just having whole chassis be ground-lifted, but still sharing ground would be enough)
Isolation on module level just makes every module much more complex to deal with (especially when/if USB would be involved)
So just... have 2 chassis designs, one which has all of the bells and whistles required to isolate the module like separate isolated power for each module and isolated data/control lines.
And the other without it, just simple shared power. Could probably be basically same PCB design, just with some 0 ohm resistors fitted on isolation-less version
As for busses, I think there are basically 2 requirements to cover, low (measuring voltages/frequency)/mid speed measurements (scanning a bunch of input channels), and high data rate that is usually sampled (logic analyzer/Oscilloscope) or streamed (SDR), with most of devices being in the first category. So ~500kbit (assuming 5k measurements/sec * 10 bytes per measurement) vs tens/hundreds
Therefore I wonder if it would be worth it to have 2 busses, low (say serial so modules itself can just talk via SCPI over serial), and high-data rate, with latter one being optional. So minimal implementation would be just micro with serial interface but that would still allow putting some more beefy modules in.
We can name it hybrid approach too, but currently the main concern is what to lay down on the chassis backplane with enough flexibility and speed and can be easily isolated. Later requirement makes USB a bad candidate but that can be addressed with applying isolation indirectly i.e. not on the USB lines but on the other side of USB interface chip (e.g. UART, SPI, etc.).
Currently I see no benefits to using a chassis backplane and a lot of problems and costs.
Something with nothing to offer is just that noting.
Then, considering whole thread is about having some kind of chassis or backplane, it is probably not for you.
But in theory it would be simple to just have 1 socket "DIB to USB" adapter (as it is just power + whatever bus it uses to talk) where you can plug any module in.