I don't mean to switch horses in the middle of a stream, nor beat a dead horse, but I think a very interesting topic here would be about the apparent very long life and stability of chips in general. I mean, like horses, if they aren't over stressed by heat, high voltages, etc.
My choice for a mission-critical instrument would be to find a horse that could handle the race.
There's the issues of resolution, repeatability, stability, precision, accuracy and drift, but these are all horses of different colors.
Mainly, I am horsing around in robotics, DIY power supplies, battery charging circuits and battery-use monitors.
Adding an additional chip to challenge the offset of a cheap opamp is something like beating a dead horse.
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Of course noise is always a problem and it is not usually something to be measured, but something that distracts measurement. Currently, Amp measurement is not easily handled by an A/D without signal conditioning(low-pass filter). Even horses are made to wear blinders.