You can do the math yourself - since YOU know the actual duty cycle that each module is running at and the actual current each module draws and the various sleep modes you plan to implement.
Since you haven't provided enough numbers and haven't quantified HOW important battery efficiency is versus additional hardware cost or even what battery voltage/capacity you are using and what the required battery life is, I'm not sure how you can expect an intelligent response to your question...
cheers,
george.