Have you been around so long that old ISA was the first analog card bus?
If so then much have changed since then.
Mini-PC is one of the newer things.
Some have an add-on card slot, but it's probably pretty short.
How much data is needed?
Unshielded 100M Ethernet would isolate, standard allows a distance up to 100m.
Industry seems to try it so that higher frequencies are in a single cage.
Cabinet walls are also pretty thick.