I don't understand why use the op-amp to get 1.65v and why you'd use such a weird regulator (with difficult to solder footprint).
A simple generic 1117-33 in to252/to-263/dpak form
for example
http://www.digikey.com/product-detail/en/NCP1117DT33G/NCP1117DT33GOS-ND/1483318http://www.digikey.com/product-detail/en/LM1117DT-3.3%2FNOPB/LM1117DT-3.3%2FNOPB-ND/363583would work just the same and be easier to heatsink with just some copper pad under it. It's not like you won't waste just as much power as heat with that LT1763 getting 3.3v out of 5v, yet you just make it harder to solder it on the board.
The 1.65v could be done with a plain 1117 adjustable in to-261 form :
http://www.digikey.com/product-detail/en/LM1117IMPX-ADJ%2FNOPB/LM1117IMPX-ADJ%2FNOPBCT-ND/3440162http://www.digikey.com/product-detail/en/SPX1117M3-L/1016-1235-5-ND/2411167Basically , rather than using 3 separate parts with capacitors and resistors, you reuse same component, reduce bom, get better prices etc.
later edit:
move the traces for rx,tx,rs all the way to the side, move the 3.3v regulator just a bit more to the center with the heatsink tab kinda where those 4 capacitors are, and your input and output capacitors by the insulation gap, away from heat. you'll have a larger area to act as a heatsink.
I'd probably put the rx,tx,rs, gnd, 3.3v on the far right side, aligned to a side and maybe with a 2row 10pin header (but 1 row, 5 pin is also ok) so that you could use commercially available cables (0.1" / 2.54mm spacing), or to just press fit it into a breadboard without blocking the whole breadboard.
Some space further to the right corner , put the gnd , 1.65v , 3 v .. again aligned at 0.1" (2.54mm, for breadboard) ... basically make it as if the holes are a DIP14 or something like that, with the middle pins missing.
Even if you don't care about breadboard, if the pins are all on one side it would be better because the pcb won't flip on the desk due to cable weight and it would use less desk space (the cables for serial won't get on the outside of the board, don't know if I explain it properly)