These are just best of my understanding and can be totally false claiming.
U1 needs decoupling capacitor.
USB hub port needs 120uF as it is minimum required (USB specification)
100uF was reference design but thous where low ESR tantalums.
You didn't have datasheet for TPS76333
You do not have capacitor at VOUT at TPS76333 (Check datasheet)
You might even change design that you do not have TPS76333 at all.
FT232 can make 3V3 so you can use that to power TUSB2036.
Datasheet says you can draw 50mA from that and TUSB2036 use 40mA.
I do not know how much J2 other end draws.
It will be close and is up to you to decide if you wanna use this.
If this is my design. I would design it so that I can use both ways.
Just add 0ohm resistor from FT232 output to 3V3 rail. If this not
work then populate TPS76333. Remember to still add needed caps.
I think usb shields should be connected together. Other wise when
you connect some random device with long cable it.
I really like idea that FT232 external supply voltage can be
selectable. See datasheet section 6.4. You can use 0ohm resistor
to jumper. Of course this is just idea and I would probably do
this this way. Also if you have room in your pcb add leds for tx
and rx. You do not even have to populate these but if something is
not working you can populate them.
I check these quickly. Check them again
MUTEP should be pulled low
VOLUP should be pulled low
VOLDN should be pulled low
DR maybe pull up? Good idea to make it easy to change after.
MUTER should be pulled low
Add led also for this. I think you have much room in your pcb.
I also think that XREGXX pins may need caps. Else they can even
oscillate. Good idea to be safe and caps there. No need to populate
right away. If you know you do not need them please leave them away
put it wasn't sure to me.
Add test point for 3V3.
Example U2 cap between trace and pins are super low. You have room so
make it bigger. Same thing with many places. No need to use minimum
what your pcb manufacturer say. That is minimum for reason. When you
do it like this (minimum caps) you are playing game which you can
ether draw or lose. Do not play that game
You have lot of room in your pcb. Redo your designators. Maybe every
text can be even right way. Maybe also add better pin 1 indicator for
ic's.
Be careful with your mounting holes. Right now they are in F.mask layer.
There might be lot of other things. But this was just small checking hope
it helps.