It's not a simplistic question at all. It's more informative to look at the graph to the left of the 60s graph; the noise spectrum. That shows that the noise of the LTZ1000 reference is near-enough white down to 3Hz. If you use an aperture of 10PLC, you are averaging over 200ms (50Hz mains), which is the period of 5Hz. Thus, at 10PLC, you are averaging very nearly white noise, which averages to zero over an infinite time. But even that white noise has a low frequency component that won't average out in 10PLC, so you're right; a problem remains.
Ultimately, all voltage references are noisy and whilst you can filter out high frequency noise, you must always use a low-pass filter (to allow the DC through) so very low frequency noise always comes through. That means you have to attend to the noise of the voltage reference. Read a few data sheets and you'll quickly find that they say to shield voltage references from air currents that can change temperature. Another issue is mechanical stress, which is why PCBs for references have cut-outs around the reference. You can prove both of these effects to yourself by lagging a voltage reference with foam and noting the improvement in noise and by pressing a scriber onto the top of a (plastic-encased) reference and seeing how you can change the voltage. There's been lots of discussion about the control circuitry around LTZ1000 to maintain constant temperature. After that, you can select references to find the most stable one. Finally, you use your meter in a stable temperature-controlled environment.