I can't believe some of the stupid selfish comments here. As others have pointed out, we used to pay $1,000s dollars once for small runs, not just $100s.
I know the costs / losses all to well, I helped start one of the first PCB manufacturing places in OZ. Yeah, we had people trying to "cheat" the system back then too, BUT at least
the customers were trying to save $1,000s not a few shitty $s. We'd talk to the customers and work out a deal. Sometimes we'd let it through, sometimes not (if a loss was involved).
I use PCBWay and others, sometimes I panelize, sometimes not. The HUMANS decide how to charge for the job, depending on how well it fits into THEIR panel.
On a big run (and IF on a rare occasion, just 1 crappy $ was important), I'd ask if there was a dimension change that would help with price, and they are always fair in response.
If you don't like their quoted price, no-one is forcing you to accept it. All this sort of "bitching" does is, possibly make these places cut costs or other measures, which often hurt
other people, than you, in the long run, for NO reason. Coming from the dark ages, I very much appreciate what we have now and the CHOICES we have !! ymmv