Soldiers going to war are every bit as likely to die (if probably more likely), and there have probably been hundreds of millions of them in history. You may reply that they were usually forced to. But many people risk their lives during work, hobby or doing extreme sports. Obviously this point makes no sense.
What can make this question at least worth asking is not about what could have made the fact impossible, which are just hypotheses and opinions, or on the opposite side, what could have made it possible, but the fact that all experimental proofs (images, videos, rock samples, testimonies, etc.) pretty much all came from only one source (the NASA) and that the experiment, even though reproduced by the NASA several times during the Apollo missions, was never reproduced by any other institution that we know of. On a scientific level, that makes it naturally questionable, as you need to resort to trust to accept it as a fact.
Of course most of the theories out there that state this never happened don't hold any more scientific value. Some have a few seemingly interesting arguments, but they are just hypotheses. Not facts. They are basically based on the opposite side of the same coin, mistrust. Mistrust is a state of mind, an opinion, not a fact.
Just a thought.