I've been to some of the UK electronic design shows over the past few years (5 or so) and Altium, Zuken and Cadence have stands and sales teams crawling all over handing out flyers and the like, not once have I seen Labcenter, I see them on the back of various electronics related magazine covers, but that's about it.
Thing is, Proteus is used in places like Plymouth uni, but I struggle to see anyone use it "professionally", some ask for Cadence, some ask for Altium (the majority in fact), some for CadStar (Zuken), even Pulsonix, and I have also seen quite a few accept EAGLE, but I don't think I have ever seen 1 (in the south west) company ask for experience in Proteus.
We have one version 7 license, but nobody uses it apart from simulation, which it is particularly good at wrt microcontrollers and such.
I like Proteus, and I can see why people useit, it does seem a bit behind the times in comparison to newer package version features, but I think if you like it, and are willing to pay the price for it (about £4k for the "full" version?) and it fulfils your needs, then use it! It's easy to use, quite a good interface, if the were to add a bit of high speed and multi trace routing like you can do on Altium it would be back in the game for me I think.
Their forums are good also, their support people are top notch!