KCS, you state you want "easy" and "relatively precise", but I guess it depends on the degree of those terms!
I have used a couple of MAX6225 devices, and right out of the box WITHOUT any adjustment, each gave 2.5000V on my 50,000 count Fluke 289. (5V devices also available). I cannot get them to budge from this figure over a reasonable range of temperatures or durations, so suspect that these devices (and maybe others) already perform much better that the spec sheets, and certainly good enough for my application.
One thing, however. Make sure you stick to the spec sheets in terms of input and output capacitive decoupling, and take the voltage reference close to the pins of the device. Otherwise, you start to gain or lose even fractions of a mV in the voltage drop in your current-carrying circuit tracks/wires.
I got my devices FREE from Maxim, who will supply engineering samples. You have to give them some reasonable expectation that you might buy more of their devices in the future! I said I was a designer (well, I am and do).