If you do data post-processing for LTspice files, you may either export CSV then import in a spreadsheet, or if you need more automation, there are Python modules that can read directly from LTspice raw files, without the need of exporting CSV.
It is also possible to run LTspice from Python, such that you can alter various parameters of a schematic in Python, then start the simulation again and again, and retrieve the results also from Python. Good for long simulations and heavy data post-procesing in Python (let it run over night and find the Python results ready next day).
You may want to know that, by default, LTspice uses lossy compression to save the produced waveforms, so the plots you see in LTspice is interpolated data after decompressing, so not 100% accurate with the simulation.
This usually doesn't matter for just looking at the plots and waveforms, but if you do more advanced processing (for example a FFT), then the artifacts caused by compression/decompression may become visible. Data compression of the LTspice results can be disabled, either from the LTspice settings, or even better, by adding the needed LTspice directives to your schematic.