So I did again (2:30am here) - FT232R against FT232H, both 9k6 8N1 xon/xoff handshake.
TeraTerm 5.2 latest, a Win10 latest on different PC.
TT_A sends 11MB loremipsum to TT_B with "Send File".
Trying to Ctrl-S and Ctrl-Q in TT_B..
It works, it stops (S) and it resumes (Q) the receving in TT_B.
Did it 3x and got Blue screen with "DPC WATCHDOG VIOLATION".
Restarted and installed TT 4.105.
The same as above, the second Blue screen in last 15 years perhaps
Restarted and looked at the FTDI drivers - both drivers from
Jan 8th 2013 (installed by the Win10 automatically, btw).
EDIT: my Win10 image was from 2018 upgraded to latest couple days back, so the old buggy driver comes from that 2018 image, imho..
Installed latest FTDI drivers manually.
Restarted and tried again (TT 4.105).
The Ctrl-S and Ctrl_Q work.
Set 921k8N1, and it still works..
While looking at the FTDI VCP drivers release notes - the xon/xoff bug was fixed in 2013
So, perhaps those chips work..