I agree with LeonR above.
One cannot assume their tools work perfectly and not infected with malware. We use backups to guard against tool failure, and various software to detect infections and malware.
Having a slower backup computer, say an old laptop, with say $30 SSD (120GB) and 4GB or more of RAM, to run a virtual machine you can roll back after experimentation, is just about perfect -- especially if you wipe the host OS every now and then; say, instead of upgrading the host OS, you wipe and install the new version from scratch.
For a single person having such a machine is probably overkill; accepting the small risk of malware burrowing through the supervisor from the VM to the host makes more sense. However, if you happen to have one, with a valid Windows license, and you tell your friends and colleagues you have it for such purposes, and are happy to lend it (especially if one were to buy a cup of coffee or something as a thank-you), having such a tool starts to make sense.
Like I said, I don't have one, and I usually avoid even using Wine, but if I had the need, I do believe I have friends who have such machines, and might be willing to run the software for me.