would agree that what I can see of the layout looks decent
for thermal dissipation you could use heatsink but at least digikey doesn't have any that small; if you really needed it I guess you would have to make your own (could also put on opposite side since you've
done the via farming fine, that way you don't worry so much about the size of the component, but it is of course less effective); but I probably wouldn't bother. Another thing is to increase the area of the copper fill; some manufacturers will specify an area that the datasheet thermal resistance is provided form, but it seems TI doesn't. It looks like they use JEDED standards, but I don't have access to them, so I've got no idea what area they would expect. Also dropping the switching frequency would decrease heat generation, but also requires larger components or increased ripple current, and it looks like you only have two options.
for the intereference issues I wouldn't expect it to affect bluetooth at all given bluetooth is very many harmonics into the switching frequency. For the analog stuff it depends a lot on the analog stuff, but if you are doing things at typical hobbyist level and have a decent layout I wouldn't expect any problems.
Not actually sure how reliable this would be, but if you are really worried maybe temporarily set it up so sampling frequency is for sure not a multiple or divisor of the switching frequency and see how much the result changes between samples. It will probably change regardless of the dcdc unless you put it in a pretty nice metal box, but if there is too much interference/noise I guess you could hack on linear regulator (and disable the switching regulator temporarily) too check if the problem is the regulator or insufficient reduction of intereference from other things.
Another related thing is the possible series I2C resistors (very small ones) to limit inrush currents; but if you add them be aware even fairly small values can stop the i2c from working and I probably just wouldn't use them here unless you have really sensetive analog circuitry (and then you have lots of other things to consider).