I've been using some of Simone's earlier versions from Tindie with only 4 pins, and they've worked great for me.
I'm using them in a noisy electrical environment (switching mains supply on & off) where other isolators didn't help and caused USB disconnects.
Looking forward to getting a bunch of these new ones with the standard 6-pin "FTDI" format connector. Upgrading my pledge from 5 to 10 pcs!