Many electromechanical structures have been built using the bare minimum amount of atoms, there is even power sources etc,
The main issue is you need to reach a certain level of complexity to actually do anything we would consider useful with them,
E.g. you want to join polymers into a single strand without using any chemical initiator (essentially spider web spinning), this could likely be accomplished by a nanomachine, but it would be a right pain to build, / test
For health / medicine, re purposing viruses and bacteria seem to be the path they are heading down now. Enter a Cell, Hijack the internals to accomplish some change, then ideally discarded, as the second they can self replicate it could cause some grief, and you can't exactly sell a health perk to the public if it spreads like the common cold.
E.g. they make a virus that patched in something that extended the length of your telomeres on the next division cycle, you would only need it to apply to a small fraction of the cells in your body to have there intended result, but if it went rampant, and kept on re patching that for every cell division, It would cause issues.