I've just built a PC (the one I'm using to write this) and the case (Deepcool Smarter) front panel LEDs were typical searchlight blue. The included case fans even had blue LEDs. Before putting any hardware in this case, all those boring and blinding blue bling LEDs were removed and replaced with red, orange and yellow LEDs.
Since finding the USB and eSATAp ports (front or back) is a lottery when the unit is hiding under a desk, I have installed LEDs behind them so they can be found easily in the dark (yellow for USB3/eSATAp, orange for USB2 and red for USB sockets for which I had no more motherboard interfaces - these are wired up directly to 5v (no data) to be used for charging purposes.
The blue LED backlighting for a media card hub/fan controller/temperature display was also replaced with a much more eye friendly yellow LED.
On an unrelated note (nothing to do with overbright LEDs), I've also put in a row of DC power jacks on an expansion slot cover plate so all the external devices (HDDs and powered speakers) can be powered from the 12v rail from the PC's power supply, avoiding all that mess associated with half a dozen wall warts and their overly long cables.