At this point I tend to agree with Berni. You start up VS, start a C# app, the toolbox with all the GUI stuff appears, you drag-n-drop, and you're off. The code is automatically generated, as are the event handlers.
Trying to shoehorn Python/Qt/Qt Designer into VS is looking like a pain, especially when GUI's are involved. Apparently you need to run QtDesigner separately to generate the .ui file, then use command line crap to convert to .py, and merge your code into that.
For those who have gone thru the hassle and it's become second nature, then yeah, it's easy. For those who have no interest in going thru the hassle, it's a freakin' pain. And at the end of the day, is there really much benefit over C#? Or is it just because it's popular? I couldn't care less what others are using, and whether it's "popular".
From what I've seen so far it's a "loose" version of C#.
In any case, does anyone know of a tutorial on setting up PyQt5 and QtDesigner, for Python, in Visual Studio, that's more recent than 6 years ago?