The main reason not to use them is they are obsolete - just looked at Farnell and Digikey and no 22V10s or 16V8s in stock. Only stock at Findchips seems to be from surplus dealers, so I'm guessing nobody's making them any more.
Modern CPLD devices are also very cheap and available - the only issue is they are generally 3.3v not 5V
An Octopart search shows hundreds to thousands of the Atmel 22V10 and 16V8 parts in stock at multiple distributors, and the parts are active, with modern form factors in 5V and 3.3V variants. I suppose if you're below 3.3V, you probably have enough horsepower to not need a GAL :-)
True, the role for GALs has diminished as cheap jellybean microcontrollers with sophisticated peripheral modules and tiny form factors are commonplace. There's just not the same need for glue logic or external state machines.
However, on infrequent occasion, a GAL is just the thing, especially modifying older designs, or in high-reliability applications. No software design reviews, validation, coding standards, etc. That being said, I haven't had occasion to use a PAL/GAL since 1989.