I just dealt with that actually.
http://www.cafelogic.com/articles-2/a-reflow-controller-for-soldering-with-a-griddle-or-toaster/See schematic/layout for analog module.
I had no trouble getting full 16-bit on input of +/- 16mV so 5V should be a piece of cake (depending on output impedance).
Bottom line is think about how your digital currents are going to return to the source and if they are going to return through your analog components. Remember that currents do not return in one piece meaning a portion will always flow through the analog section. The point being that if the digital return path is twice as good (1/2 the impedance), you'll still have 33% flow back through the analog.
Don't run high speed traces across breaks in your ground plane. If you don't have a power plane, use traces at least three time fatter than normal for your power and consider using a separate linear regulator to power the analog.
If you don't have a ground plane, you are going to have a hard to time achieving 16-bit.
For the power-noise, use an external precision reference with good PSRR.
Last thing, consider the bandwidth you need and construct an RC filter at the input of your ADC that filters out higher frequency.
Oh yeah, big ass low-esr bypass caps on all ICs.