As long as you take care of the extremes, the rest should be fine. Other then knowing switching frequency, you can do the calculations without looking at the data sheet for the switching devices at the start. You have to eventually to make sure your parameters are within the specs for the regulator IC.
He is an example, you are designing an inductor-based boost converter that takes from 2.8V to 4.5V input and you want 5V to 25V output at 2A.
I would first go to one of the most important extremes - the highest voltage at the highest current with the lowest input voltage. That's a 9:1 output:input voltage ratio, so with ideal parts, the inductor will be charging 90% of the cycle, and discharging 10%. The average current out is 2A, so the average current during the 10% discharge time is 20A. Now how much are you going to allow the current in the inductor to discharge during that 10% ? Pick two extremes. It the first, it only discharges by 5%. In the second, it discharges by 100%. In the first, the peak inductor current will be 2 x 5%/2 = 20.5A. In the second case the peak current will be 40A. We know we will have inefficiencies so lets boost those numbers by 20%. We have to allow for component tolerances so add another 20% on top. That gives a peak inductor current between 30A and 58A. Now you look at the spec sheets for the inductors, the regulator, the MOSFET's, can you work at either end of those current specs.
At switch-on you probably want some extra power available to get up to working voltage, so can the components be pushed an extra 20% for a one off start?
If the numbers just do not work, then a single inductor solution will not work and you will have to go to a transformer. With a transformer, you could reduce the peak current to more like 4A to 8A for these specs.
Then you look at what happens again at the minimum voltage in and maximum power output conditions - probably will be at 25V out. With the two inductors chosen, if the load changes from 0% to 100%, how many cycles will it take for the current in the inductor to build up to the required level? The bigger inductor will take something like 10 times longer then the small inductor. During this time the output will droop by an amount. The size of the filter caps on the output will decide the amount of the droop as they have to sustain the current until the current in the inductor can build up.
You might want to look at how quickly the output voltage can change, if that is of importance.
Notice I have been talking voltages and currents, but I haven't touched the device spec sheet much. I now at least have a feel for the numbers, and an idea if it is possible. If it looks possible, pick a real inductor, real mosfets, etc and repeat the calculations in more detail allowing, regulators speca such as minimum ON time for resistance of the inductor windings, Diode voltage drops if it uses diodes, resistance of the mosfet, rise and fall times of the mosfets, and regulator specs such as minimum ON time/OFF times.
If it works comfortably, you have your solution. If not, you probably either can guess what values you do need, or you will know that the specs need rethinking.
Richard.