The old Keithley picoampere current sources are actually a calibrated voltage source followed by a switchable high-value resistor, of the same resistor construction used in their electrometers. These work well into a low-impedance load, such as the virtual ground of an I-V amplifier. The calibration routine requires shorting the input protection resistor in the electrometer, but I find it easier to just tweak the voltage to include that resistor in series with the source's internal output resistor. With proper shielding, etc., it is straightforward to do this with a good voltage source (more than 1 V, preferably more than 10 V) and high-value resistors.