Looks nice.
My suggestions would be ... do you really need a 220uF capacitor on the output of that LDO?
And two ... looks like an annoyance to have just three surface mounted resistors on the bottom of the board. You could have that bottom completely empty and lifted off the board by just the leads and solder there... so you could use for example a double sided sticky tape to attach the board to a box or something.
All your resistors are 10k ... I'd consider for example using a 4 resistor array on the other side of the board for example something
like thisIt could go for example where it says PRG ... shift RST button a bit up, rotate the PRG button by 90 degrees and slide it up a bit , basically the two buttons should line up ...
You have some wasted board space in that corner . If you move the LDO down below the 5v print you can move the 22uF electrolytic closer to the top corner and shift the reset button up where the capacitor is now. Maybe leave more room for that capacitor (make a standard 5mm lead spacing and leave 6-8mm diameter in case you want to put 47-100uF instead of 22uF, and basically make sure you don't touch the ldo with the capacitor, why heat the capacitor with the ldo?)
Lots of board space used by that 220uF capacitor ... there's plenty of 5 / 6.3 mm x 8-11 mm polymers out there (or smaller at 6mm tall, but considering the to-92 regulator is about 10-11mm tall, what's the point spending more for a smaller height cap?) ... for example
this 220uF 6.3v one with 2 mm lead spacing , 5mm x 8 mm, 0.18$ if you buy 100, 0.3$ if you buy 10.
Or a 100uF 10v electrolytic that's 6.3mm x 6.3mm is around 0.15$ for 10pcs ...
Rubycon ML with 3k hours @ 105c ... do you need more for a LDO?
Looking at the HT7333 datasheet, the TO-92 regulator doesn't come with the leads formed that way, they're on tap in straight line with 2.5mm spacing, see
datasheet page 10 - do you have other regulator that comes with leads bent in that shape, or you're planning to shape the leads and make the regulator sit above the pcb by some distance to have one lead bent that way? You could have all three holes in straight line.