If you order PCB to being scored (word from Google translator, not sure) then you simply break out each PCB.
To ensure be clear: PCB gets V shape grooves on both sides leaving only a thin connection, easy to break.
The other solution is milling. To make panel for milling PCBs need be positioned in some distance (typically 2mm, I think).
I let making panel to contract manufacturer or PCB manufacturer as they know how many PCBs use at one panel to be optimal for format they use.