Existential question... why are you making this at all? Surely you can buy one of these off the shelf.
FT231XS is a "Full Speed" device, so its signalling tops out at 3.3V CMOS and does not require high speed differential considerations (like single digit pF caps).
You can save the extra caps by using somewhat meatier devices (like zeners directly, or schottky). I would just as well nix the 47pF caps and special ESD device and use a pair of BAT54S (of course, this costs stray inductance due to package design and layout). But either is OK.
The IP4234 doesn't specify the "R" between clamp diodes; there's an "Rs" spec, but it's not defined what this is... A better choice might be one that does explicitly incorporate RC filtering, and specifies series resistance and capacitance. Think there's an On Semi USB filter/ESD clamp device out there but I don't remember the part number offhand. In that case, you won't have to worry about the series resistors either.
C1 should be much larger if using clamp diodes, otherwise, the local zener/TVS in the clamp device will handle transients.
The ferrite bead is unnecessary; if you want to reduce power line noise, or hot-plugging transients, use separate filtering, or a series resistor, or an active current limiting circuit (kind of unnecessary as the other end of the USB port is required to have such a limiting device as-is). This might be interesting on the serial end, as RS-232 related devices I don't think are supposed to run over 10 or 20mA, or something like that. But if you're not following a particular standard, word for word (i.e., the traditional DE-9 async serial connector, TIA-574), you can of course do whatever suits your purpose. As shown, a short on the serial end (pin 5 to 9) will brown out the USB port, causing it to disconnect (and throw a power consumption fault, if so equipped).
Only thing that jumps out to me: GROUND THOSE SHIELDS! There IS no "oh, I'll just connect this through a jumper / resistor / capacitor / etc. and it'll be alright", no, the days of that are long gone. Anyone who says you can connect a shield loosely is at best ignorant (repeating a very old suggestion, but never having tested it himself). Even if you limit signal bandwidth on your end, you can't escape the low-frequency energy delivered by ESD or EFT events without compromising the signals themselves, and you can't address the transients that propagate back up the cable to the host end.
Tim