Of course you can, just connect the speakers(serial or parallel) and plug it in one channel of the board(and then do the same for second channel).
The only problem is you need to choose appropriate speakers in order to have a good volume and not overload the amp(look for specks to calculate what speakers you need).
And of course you will have just L and R channels of stereo with this board, if you want to do some kind of 5.1 sound with different sound going to different speaker you will need different board.